WFU

2016年11月17日 星期四

異體移植前評估項目

Recipient Pre- Stem Cell Transplantation Evaluation Protocol

基本資料:
Dx: ____________ ___________
Disease status: □CR □PR □Refractory
MRD: □ (+) □ (-)
Conditioning regimen: _______________________
移植種類 : □autologous □allogeneic □syngeneic
異體移植 : □sibling □unrelated □family donor □identical twin
幹細胞來源 : □PBSC □BMSC □cord blood

照會
Neurology
Psychiatry
Ophthalmology
ENT (請先照好para-nasal sinus X-ray) 已涵蓋於BMT醫令套餐內
Dentist (如須進一步處理,如拔牙,請先通知VS)
Gynecology (女性病患適用)
請加做 FSH, LH, E2, P4,如須保存卵子請告知婦產科
(排卵藥需在月經開始時就給,需入手術室全麻取卵) (自費)
Urology (男性病患適用)
如需保留精子請聯絡泌尿科門診for sperm analysis and collection (分機: 67590, 67591) (自費)
Dermatology
營養師
[Optional] Radio-oncology:
請詢問VS是否會用Total Body Irradiation (TBI) conditioning



ENT and Chest exams
Para-nasal sinus X-ray
(如過去有鼻竇炎病史, para-nasal x-ray有異常, 請加做sinus CT)
CXR (PA view)
Chest HRCT (如病人為lymphoma, 或有liver abscess等病史,
請詢問主治醫師是否改為neck/chest/abd/pelvis CT with/without contrast)
Lung volume with FRC (standard spirometry) + DLCO

Cardiac functions
EKG
Cardiac echo
[optional] RNA study for LVEF evaluation (如有心臟功能不佳病史,或曾使用多次Anthracycline-based chemotherapy, 請安排

GI tract exams
Stool OB
Abdominal echo
請確認有無hemorrhoid/ peri-anal pain/ abscess history/fistula

Transfusion/Immunology
Ferritin, iron TIBC
ABO and Rh typing (在檢驗項目transfusion/blood type)
Anti-A (IgM), Anti-B (IgM) titer
IgG, IgA, IgM Serum protein electrophoresis (SPEP)

Hematology
確認病患與捐贈者的HLA ABC/DR/DQ high resolution DNA結果相符
並請單獨記錄成BMT-donor note (donor姓名、病歷號及HLA data)
Pre-BMT STR (Auto免做)

Infections
HBV profile (HBsAg, anti-HBs, IgG anti-HBc)
若為下列兩種情況1 HBsAg(-)anti-HBc(-)  2 HBsAg(+)
請加做HBV viral load. Anti-HBeHbeAg
Anti-HCV (如果抗體陽性, 加做HCV RNA viral load)
HIV (anti-HIV 1/2 screening)
HTLV 1/2 (Anti-HTLV1/2 Ab qualitative)
CMV (IgM anti-CMV, IgG anti-CMV, CMV viral load)
EBV (IgM anti-VCA, IgG anti-VCA, IgA anti-VCA, IgG anti-EA, IgA anti-EA,EBNA Ab, EBV viral load)
VZV (IgG anti-VZV)
Serum Aspergillus Ag
VDRL test (在檢驗項目Immunology/Bacteria)

Pan-cultures
Nasal swab culture for bacteria/ fungus
Throat swab culture for bacteria/ virus/ fungus
Sputum culture+ Gram stain; Sputum AFS+TB ; Sputum fungus culture
Urine culture
Anal swab culture & anal swab VRE
Stool culture & Clostridium
Blood culture & Blood fungus culture
如有wound/水泡,加做wound swab culture for bacteria.fungus/ virus

Endocrine
TSH. Free T4

其他重要事項
請詢問病患、家屬,及整理歷次住院病歷後,更新藥物過敏病史。
移植前衛教: 請通知5PW/ 3D1 護理長安排移植前衛教
                 (5PW分機: 70533 / 3D1分機: 62415)
確認病人一周內是否有 CBC / BCS data,若無請加做檢驗。
VS討論後,決定是否做disease status evaluation,例如:
(1) Leukemia: BM study, cytogenetics, FISH, flowcytometric MRD,ph(+)->Bcr-Abl,NPM1/FLT3 etc follow up.
(2) Lymphoma: BM study, X-ray, CT, MRI, PET etc
(3) Myeloma: serum IFE, β 2-microglobulin, spot urine EP + IFE, 24-hrs urine κ /λ 定量,serum free κ /λ ratio
如需做Bone marrow study, 請通知BMT or 12D CR (分機: 63629)
若病患診斷非AML / ALL / CML / AA ,且需作Allo-HSCT,請聯絡主治醫師事前申請移植。
藥物申請:請詢問VS conditioning regimen是否會用到須事先申請用藥 (ex. Fludarabine,Anti-CD52, BCNU) ,如果是請通知BMT or 12D CR填事前申請書或確認庫存(分機: 63629)
預備接受sibling-allo-PBSCT, 請聯絡血庫VS羅仕錡確認day0/day1已排程 (分機:65398, GSM 51637),並請捐贈者確認血管。
如預計接受自捐血 (during auto-BM-harvest backup in OR) 或尋找HLA-matched PLT, 請通知血庫VS羅仕錡 (分機: 65398, GSM 51637) or 盧先生 (分機: 62151)